Cell-specific loss of κ-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse
Copyright policy )Cell-specific loss of κ-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse
Jimpy is a murine mutation in myelin proteolipid protein, leading to premature death of oligodendrocytes and severe central nervous system hypomyelination. Jimpy is a bona fide model of human Pelizaeus-Merzbacher disease. This paper describes a severe reduction in expression of kappa-opioid receptors (KOP) in oligodendrocytes of jimpy mice. A cell-specific reduction of >90% is apparent by 5 days of age. Expression is not reduced in neurons, and mu-opioid receptor expression is normal. Mechanism(s) leading to deficient KOP expression in jimpy mice remain unclear. We speculate that loss of KOP may be related to increased [Ca(2+)](i) and premature death of jimpy oligodendrocytes.
- University of Kentucky United States
- Virginia Commonwealth University United States
Mice, Jimpy, Cell Death, Pelizaeus-Merzbacher Disease, Receptors, Opioid, kappa, Down-Regulation, Nerve Fibers, Myelinated, Disease Models, Animal, Hereditary Central Nervous System Demyelinating Diseases, Mice, Oligodendroglia, Animals, Calcium Signaling
Mice, Jimpy, Cell Death, Pelizaeus-Merzbacher Disease, Receptors, Opioid, kappa, Down-Regulation, Nerve Fibers, Myelinated, Disease Models, Animal, Hereditary Central Nervous System Demyelinating Diseases, Mice, Oligodendroglia, Animals, Calcium Signaling
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