Distribution of transcripts for the brain‐specific GDP/GTP exchange factor collybistin in the developing mouse brain
Copyright policy )Distribution of transcripts for the brain‐specific GDP/GTP exchange factor collybistin in the developing mouse brain
AbstractThe dbl‐like GDP/GTP exchange factor, collybistin, binds to the receptor anchoring protein gephyrin and activates the Rho‐like GTPase Cdc42. Collybistin was found in two splice variants I and II, both of which share a tandem Dbl homology/pleckstrin homology (DH/PH) domain. In heterologous expression systems, collybistin II induces the formation of submembraneous gephyrin aggregates and therefore has been implicated in inhibitory synapse formation. Expression of collybistin is restricted to neuronal tissues and is predominantly found in brain. Here, we investigated the spatio‐temporal distribution of collybistin transcripts in the embryonic mouse brain and compared it to gephyrin and glycine receptor mRNA patterns. Our data show that collybistin expression is upregulated when neurons become postmitotic and start to differentiate.
- Max Planck Society Germany
- Max Planck Institute for Brain Research Germany
Cerebral Cortex, Neurons, Brain, Gene Expression Regulation, Developmental, Membrane Proteins, Cell Differentiation, Receptors, GABA-A, Guanosine Diphosphate, Hippocampus, Olfactory Bulb, Cell Line, Mice, Cerebellum, Ganglia, Spinal, Animals, Guanine Nucleotide Exchange Factors, Guanosine Triphosphate, RNA, Messenger, Carrier Proteins, In Situ Hybridization
Cerebral Cortex, Neurons, Brain, Gene Expression Regulation, Developmental, Membrane Proteins, Cell Differentiation, Receptors, GABA-A, Guanosine Diphosphate, Hippocampus, Olfactory Bulb, Cell Line, Mice, Cerebellum, Ganglia, Spinal, Animals, Guanine Nucleotide Exchange Factors, Guanosine Triphosphate, RNA, Messenger, Carrier Proteins, In Situ Hybridization
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