Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives
Copyright policy )Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives
Obese (BMI 26 kg/m2; n=51) and lean (BMI <26 kg/m2; n=61) Caucasian patients with severe, familial essential hypertension, were compared with respect to genotype and allele frequencies of a HincII RFLP of the low density lipoprotein receptor gene (LDLR). A similar analysis was performed in obese (n=28) and lean (n=68) nonmotensives. A significant association of the C allele of the T → C variant responsible for this RFLP was seen with obesity (x2=4.6, P=0.029) in the hypertensive, but not in the normotensive, group (odds ratio=3.0 for the CC genotype and 2.7 for CT). Furthermore, BMI tracked with genotypes of this allele in the hypertensives (P=0.046). No significant genotypic relationship was apparent for plasma lipids. Significant linkage disequilibrium was, moreover, noted between the HincII RFLP and an ApaLI RFLP (x2=33, P<0.0005) that has previously shown even stronger association with obesity (odds ratio 19.6 for cases homozygous for the susceptibility allele and 15.2 for heterozygotes). The present study therefore adds to our previous evidence implicating LDLR as a locus for obesity in patients with essential hypertension.
- University of Sydney Australia
- Queensland University of Technology Australia
- Griffith University Australia
- Royal North Shore Hospital Australia
Male, obesity, Etiology, genotype, lipid blood level, Linkage Disequilibrium, Middle Age, Plasma lipids, Receptors, Non-U.S. Gov't, Deoxyribonucleases, Type II Site-Specific, Body mass index, restriction fragment length polymorphism, risk, Deoxyribonucleases, adult, Homozygote, allele, article, Chromosome 19, Type II Site-Specific, Middle Aged, homozygote, receptor gene, PCR, female, Cholesterol, Phenotype, priority journal, Hypertension, RFLP, Female, Support, Polymorphism, Restriction Fragment Length, Heterozygote, gene locus, Genotype, Low density lipoprotein receptor, Clinical Sciences, gene frequency, LDL, male, lipid, 616, Genetics, Humans, Point Mutation, controlled study, human, Obesity, Polymorphism, Cross-sectional study, Alleles, Body Weight, essential hypertension, DNA, heterozygote, major clinical study, body mass, gene linkage disequilibrium, Restriction Fragment Length, Receptors, LDL, Genetic markers, caucasian
Male, obesity, Etiology, genotype, lipid blood level, Linkage Disequilibrium, Middle Age, Plasma lipids, Receptors, Non-U.S. Gov't, Deoxyribonucleases, Type II Site-Specific, Body mass index, restriction fragment length polymorphism, risk, Deoxyribonucleases, adult, Homozygote, allele, article, Chromosome 19, Type II Site-Specific, Middle Aged, homozygote, receptor gene, PCR, female, Cholesterol, Phenotype, priority journal, Hypertension, RFLP, Female, Support, Polymorphism, Restriction Fragment Length, Heterozygote, gene locus, Genotype, Low density lipoprotein receptor, Clinical Sciences, gene frequency, LDL, male, lipid, 616, Genetics, Humans, Point Mutation, controlled study, human, Obesity, Polymorphism, Cross-sectional study, Alleles, Body Weight, essential hypertension, DNA, heterozygote, major clinical study, body mass, gene linkage disequilibrium, Restriction Fragment Length, Receptors, LDL, Genetic markers, caucasian
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