Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Copyright policy )Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.
- University of Tokyo Japan
- Hokkaido Bunkyo University Japan
Epilepsy, Amino Acid Transport System X-AG, Pyramidal Cells, Brain, Glutamic Acid, Biological Transport, Electroencephalography, Hippocampus, Synaptic Transmission, Mice, Inbred C57BL, Mice, Brain Injuries, Gene Targeting, Nerve Degeneration, Synapses, Animals, ATP-Binding Cassette Transporters
Epilepsy, Amino Acid Transport System X-AG, Pyramidal Cells, Brain, Glutamic Acid, Biological Transport, Electroencephalography, Hippocampus, Synaptic Transmission, Mice, Inbred C57BL, Mice, Brain Injuries, Gene Targeting, Nerve Degeneration, Synapses, Animals, ATP-Binding Cassette Transporters
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