PAR-1 for the Course of Neurodegeneration
Copyright policy )PAR-1 for the Course of Neurodegeneration
The large number of kinases that phosphorylate the microtubule binding protein tau has posed a challenge to understanding their individual roles in turning this protein into a killer of neurons. A study in this issue of Cell (Nishimura et al., 2004) uses an elegant fusion of loss-of-function genetics and transgenic overexpression to make the case that the PAR-1 kinase stands at the head of a temporally ordered series of tau phosphorylations.
- National Cancer Institute United States
Neurons, Biochemistry, Genetics and Molecular Biology(all), Neurodegenerative Diseases, tau Proteins, Protein Serine-Threonine Kinases, Animals, Genetically Modified, Drosophila melanogaster, Animals, Humans, Phosphorylation, Caenorhabditis elegans Proteins
Neurons, Biochemistry, Genetics and Molecular Biology(all), Neurodegenerative Diseases, tau Proteins, Protein Serine-Threonine Kinases, Animals, Genetically Modified, Drosophila melanogaster, Animals, Humans, Phosphorylation, Caenorhabditis elegans Proteins
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