Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF‐β homologue decapentaplegic
Copyright policy )Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF‐β homologue decapentaplegic
The dorsal surface of the Drosophila embryo is formed by the migration of the lateral epithelial cells to cover the amnioserosa. The Drosophila cJun-N-terminal kinase (DJNK) is essential for this process. Mutations in DJNK or the DJNK activator hemipterous (HEP) lead to incomplete dorsal closure, resulting in a hole in the dorsal cuticle. The molecules downstream of DJNK in this signaling pathway have not been established. Here we demonstrate that the basket1 (bsk1) mutation of DJNK causes decreased interaction with DJUN. Expression of decapentaplegic (DPP), a TGF-beta homologue, in the leading edge of the dorsal epithelium, is identified as a genetic target of the JNK pathway. A constitutive allele of JUN is able to rescue the dorsal closure defect of bsk1 and restores DPP expression. Furthermore, ectopic DPP rescues the defects in dorsal closure caused by bsk1. These data indicate that the interaction of DJNK with DJUN contributes to the dorsal closure signaling pathway and targets DPP expression.
- University of Massachusetts Medical School United States
- Howard Hughes Medical Institute United States
Activating Transcription Factor 2, Proto-Oncogene Proteins c-jun, Genetic Complementation Test, JNK Mitogen-Activated Protein Kinases, Gene Expression Regulation, Developmental, Epithelial Cells, Genes, Insect, Calcium-Calmodulin-Dependent Protein Kinases, Ectoderm, Morphogenesis, Animals, Drosophila Proteins, Insect Proteins, Point Mutation, Drosophila, Mitogen-Activated Protein Kinases, Cyclic AMP Response Element-Binding Protein, Protein Binding, Signal Transduction, Transcription Factors
Activating Transcription Factor 2, Proto-Oncogene Proteins c-jun, Genetic Complementation Test, JNK Mitogen-Activated Protein Kinases, Gene Expression Regulation, Developmental, Epithelial Cells, Genes, Insect, Calcium-Calmodulin-Dependent Protein Kinases, Ectoderm, Morphogenesis, Animals, Drosophila Proteins, Insect Proteins, Point Mutation, Drosophila, Mitogen-Activated Protein Kinases, Cyclic AMP Response Element-Binding Protein, Protein Binding, Signal Transduction, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).44 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!