Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway
Copyright policy )Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function. Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability.
- National Institute of Health Pakistan
- National Cancer Institute United States
- National Institutes of Health United States
- Lawrence Berkeley National Laboratory United States
- National Cancer Institute Ukraine
Heterozygote, Genotype, Models, Genetic, Cell Survival, Genetic Vectors, Telomere-Binding Proteins, Mice, Transgenic, DNA, Polymerase Chain Reaction, Mice, Mutant Strains, Mice, Inbred C57BL, Blotting, Southern, Mice, Blastocyst, Gene Targeting, Mutation, Animals, Telomerase, Protein Binding, Repetitive Sequences, Nucleic Acid
Heterozygote, Genotype, Models, Genetic, Cell Survival, Genetic Vectors, Telomere-Binding Proteins, Mice, Transgenic, DNA, Polymerase Chain Reaction, Mice, Mutant Strains, Mice, Inbred C57BL, Blotting, Southern, Mice, Blastocyst, Gene Targeting, Mutation, Animals, Telomerase, Protein Binding, Repetitive Sequences, Nucleic Acid
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