Isoproterenol Exacerbates a Long QT Phenotype in Kcnq1-Deficient Neonatal Mice: Possible Roles for Human-Like Kcnq1 Isoform 1 and Slow Delayed Rectifier K+ Current
Copyright policy )Isoproterenol Exacerbates a Long QT Phenotype in Kcnq1-Deficient Neonatal Mice: Possible Roles for Human-Like Kcnq1 Isoform 1 and Slow Delayed Rectifier K+ Current
To determine whether the neonatal mouse can serve as a useful model for studying the molecular pharmacological basis of Long QT Syndrome Type 1 (LQT1), which has been linked to mutations in the human KCNQ1 gene, we measured QT intervals from electrocardiogram (ECG) recordings of wild-type (WT) and Kcnq1 knockout (KO) neonates before and after injection with the beta-adrenergic receptor agonist, isoproterenol (0.17 mg/kg, i.p.). Modest but significant increases in JT, QT, and rate-corrected QT (QTc) intervals were found in KO neonates relative to WT siblings during baseline ECG assessments (QTc = 57 +/- 3 ms, n = 22 versus 49 +/- 2 ms, n = 28, respectively, p 88% amino acid identity) between the predominant human and mouse cardiac Kcnq1 isoforms.
- University of Washington Medical Center United States
- Georgetown University Medical Center United States
Mice, Knockout, Potassium Channels, KCNQ Potassium Channels, Sequence Homology, Amino Acid, Molecular Sequence Data, Isoproterenol, Action Potentials, Adrenergic beta-Agonists, Long QT Syndrome, Mice, Phenotype, Potassium Channels, Voltage-Gated, KCNQ1 Potassium Channel, Animals, Humans, Amino Acid Sequence, Delayed Rectifier Potassium Channels
Mice, Knockout, Potassium Channels, KCNQ Potassium Channels, Sequence Homology, Amino Acid, Molecular Sequence Data, Isoproterenol, Action Potentials, Adrenergic beta-Agonists, Long QT Syndrome, Mice, Phenotype, Potassium Channels, Voltage-Gated, KCNQ1 Potassium Channel, Animals, Humans, Amino Acid Sequence, Delayed Rectifier Potassium Channels
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