Analysis of EIF4G1 in Parkinson's disease among Asians
Copyright policy )Analysis of EIF4G1 in Parkinson's disease among Asians
Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.
- National Neuroscience Institute Singapore
- National University of Singapore Singapore
- National University of Singapore Libraries Singapore
- Tan Tock Seng Hospital Singapore
- Genome Institute of Singapore Singapore
Genetic Markers, Male, Parkinson's disease, 610, Parkinson Disease, Exons, Middle Aged, Gene, Polymorphism, Single Nucleotide, United Kingdom, Asian People, Risk Factors, Prevalence, Humans, Female, Genetic Predisposition to Disease, Eukaryotic Initiation Factor-4G, Aged
Genetic Markers, Male, Parkinson's disease, 610, Parkinson Disease, Exons, Middle Aged, Gene, Polymorphism, Single Nucleotide, United Kingdom, Asian People, Risk Factors, Prevalence, Humans, Female, Genetic Predisposition to Disease, Eukaryotic Initiation Factor-4G, Aged
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