Effect of glutamine on lymphoplasmacytic lymphoma, especially on the viewpoint of the differentiation into vulnerable subpopulation

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2018 English Publisher:Elsevier BVJournal:Pathology - Research and Practice, volume 214, pages 1,667-1,674 (issn: 0344-0338,

Authors: Naoki, Wada; Satoshi, Nojima; Shin-Ichiro, Tahara; Kenji, Ohshima; Masako, Kurashige; Keisuke, Kawasaki; Mitsuyo, Tone; +3 Authors

doi: 10.1016/j.prp.2018.08.019

pmid: 30173943

Effect of glutamine on lymphoplasmacytic lymphoma, especially on the viewpoint of the differentiation into vulnerable subpopulation

- Summary
- Subjects
- Related research
  (8)
- Metrics

tips_and_updates
Recommended

Abstract

Glutamine (Gln) is important not only for cell proliferation but also for differentiation. Although Gln is essential for plasmacytic differentiation of lymphocytes, no study has been done on the effect of Gln on differentiation of tumor cells, such as lymphoma. Here we examined the effect of Gln on plasmacytic differentiation of lymphoplasmacytic lymphoma (LPL) with its cell lines, MWCL-1 and RPCI-WM1. Gln promoted plasmacytic differentiation of LPL, and p38 MAPK signaling pathway mediated such differentiation. We previously reported that the subpopulation with plasmacytic differentiation was vulnerable to apoptosis in LPL. Although it is difficult to lead these findings to the radical therapy, they might help the treatment of LPL, in which stimulation of p38 MAPK by Gln induced differentiation of LPL into vulnerable subpopulation.

Related Organizations

Osaka Gakuin University
Japan
Osaka University
Japan

Keywords

Cell Line, Tumor, Glutamine, Plasma Cells, Humans, Apoptosis, Cell Differentiation, Waldenstrom Macroglobulinemia, Cell Proliferation

8 Research products, page 1 of 1

GLI Transcription Factors Modulate IgM Secretion In Waldenström Macroglobulinemia
2013IsAmongTopNSimilarDocuments
A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia
2014IsAmongTopNSimilarDocuments
Drug Resistance Alters CD38 Expression and in Vitro Response to Daratumumab in Waldenstrom Macroglobulinemia Cells
2016IsAmongTopNSimilarDocuments
Methylation Patterns in Waldenströms Macroglobulinemia Cells That Are Inherently Resistant or Have Acquired Resistance to Bortezomib, Converge on the TP63 and Cepba Family of Transcription Factors
2014IsAmongTopNSimilarDocuments
Whole Genome and Transcriptome Analysis of Waldenstrom's Cell Lines Show Preservation of Many Important Genomic Features of Primary Disease, and Identify a Non-L265P Mutation in MYD88
2015IsAmongTopNSimilarDocuments
Mir-155 Expression Raises the Apoptotic Threshold in Waldenström Macroglobulinemia By Inhibition of FOXO3a and Bim
2014IsAmongTopNSimilarDocuments
Heterogeneous Bcl-2 Family Expression In Waldenström Macroglobulinemia Determines Response To Inducers Of Intrinsic Apoptosis
2013IsAmongTopNSimilarDocuments
Immunophenotyping of Waldenströms Macroglobulinemia Cell Lines Reveals Distinct Patterns of Surface Antigen Expression: Potential Biological and Therapeutic Implications
2015IsAmongTopNSimilarDocuments

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average