Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia
Copyright policy )Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia
Abnormalities of serotonin synthesis and metabolism may be associated with suicidality. The serotonin transporter gene (5-HTT) is one of the important genes involved in the regulation of serotonin neurotransmission. We examined the association of suicidal behavior in Chinese schizophrenic patients with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR). The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal and 262 non-suicidal patients with a diagnosis of schizophrenia (DSM-IV criteria). All subjects were unrelated to each other, and all were Chinese. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with history of attempted suicide. From our results, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behavior in Chinese patients with schizophrenia.
- National University of Singapore Singapore
- National University of Singapore Libraries Singapore
- National Neuroscience Institute Singapore
Adult, Male, China, Serotonin, 610, Gene Expression, Nerve Tissue Proteins, 5-HTTLPR, Polymerase Chain Reaction, Ethnic, 616, Humans, Promoter Regions, Genetic, Alleles, Serotonin Plasma Membrane Transport Proteins, Singapore, Membrane Glycoproteins, Polymorphism, Genetic, Membrane Transport Proteins, Middle Aged, Polymerase chain reaction, Schizophrenia, Female, Schizophrenic Psychology, Carrier Proteins
Adult, Male, China, Serotonin, 610, Gene Expression, Nerve Tissue Proteins, 5-HTTLPR, Polymerase Chain Reaction, Ethnic, 616, Humans, Promoter Regions, Genetic, Alleles, Serotonin Plasma Membrane Transport Proteins, Singapore, Membrane Glycoproteins, Polymorphism, Genetic, Membrane Transport Proteins, Middle Aged, Polymerase chain reaction, Schizophrenia, Female, Schizophrenic Psychology, Carrier Proteins
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