RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
Copyright policy )RETRACTED: Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
UnSIRT6ain Repair Efficient and accurate repair of double-strand DNA breaks is critical for genome stability and involves a process known as homologous recombination. During repair of the sheared ends, the DNA must be resected by trimming one of the two strands on either side of the break. For the repair to be accurate, the remaining single-stranded DNA (ssDNA) has to be bound by the ssDNA-binding protein, RPA, after which the ssDNA can then bind homologous sequences. Kaidi et al. (p. 1348 ) found that the mammalian deacetylase, SIRT6 (which has been implicated in maintaining genome stability), was critical for resection. At sites of DNA damage, SIRT6 deacetylated and activated CtIP (a protein important for resection), ensuring that resection occurred at the appropriate place and time.
- University of Cambridge United Kingdom
- University of Copenhagen Denmark
Niacinamide, Endodeoxyribonucleases, DNA Repair, Cell Cycle, DNA, Single-Stranded, Nuclear Proteins, Acetylation, DNA, Genomic Instability, Cell Line, Mice, Cell Line, Tumor, Animals, Humans, Camptothecin, DNA Breaks, Double-Stranded, Mutant Proteins, Carrier Proteins, Cell Proliferation, Protein Binding
Niacinamide, Endodeoxyribonucleases, DNA Repair, Cell Cycle, DNA, Single-Stranded, Nuclear Proteins, Acetylation, DNA, Genomic Instability, Cell Line, Mice, Cell Line, Tumor, Animals, Humans, Camptothecin, DNA Breaks, Double-Stranded, Mutant Proteins, Carrier Proteins, Cell Proliferation, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).331 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!