Function of theDrosophilareceptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance
Copyright policy )Function of theDrosophilareceptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance
The second messengers cAMP and cGMP modulate attraction and repulsion mediated by neuronal guidance cues. We find that the Drosophila receptor guanylyl cyclase Gyc76C genetically interacts with Semaphorin 1a (Sema-1a) and physically associates with the Sema-1a receptor plexin A (PlexA). PlexA regulates Gyc76C catalytic activity in vitro, and each distinct Gyc76C protein domain is crucial for regulating Gyc76C activity in vitro and motor axon guidance in vivo. The cytosolic protein dGIPC interacts with Gyc76C and facilitates Sema-1a-PlexA/Gyc76C-mediated motor axon guidance. These findings provide an in vivo link between semaphorin-mediated repulsive axon guidance and alteration of intracellular neuronal cGMP levels.
- Johns Hopkins University School of Medicine United States
- Howard Hughes Medical Institute United States
- Johns Hopkins Medicine United States
Motor Neurons, Embryo, Nonmammalian, Neurogenesis, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Receptors, Cell Surface, Semaphorins, Axons, Catalysis, Drosophila melanogaster, Guanylate Cyclase, Animals, Drosophila Proteins, Carrier Proteins, Cyclic GMP, Cells, Cultured, Protein Binding, Sequence Deletion, Signal Transduction
Motor Neurons, Embryo, Nonmammalian, Neurogenesis, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Receptors, Cell Surface, Semaphorins, Axons, Catalysis, Drosophila melanogaster, Guanylate Cyclase, Animals, Drosophila Proteins, Carrier Proteins, Cyclic GMP, Cells, Cultured, Protein Binding, Sequence Deletion, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!