Higher 5-HT1A Receptor Binding Potential During a Major Depressive Episode Predicts Poor Treatment Response: Preliminary Data from a Naturalistic Study
Copyright policy )Higher 5-HT1A Receptor Binding Potential During a Major Depressive Episode Predicts Poor Treatment Response: Preliminary Data from a Naturalistic Study
Serotonin 1A (5-HT1A) binding potential (BP) as assessed by positron emission tomography (PET) is higher in major depressive disorder (MDD) in association with the higher expressing GG genotype of the 5-HT1A C-1019G polymorphism. We hypothesize that higher 5-HT1A BP and the GG genotype predict remission failure on antidepressant treatment. We determined 5-HT1A BP by PET and 5-HT1A C-1019G genotype in 43 controls and 22 medication-free MDD subjects. MDD was treated naturalistically and remission was defined as >50% reduction and a score of
- Columbia University United States
- King’s University United States
- University of York United Kingdom
- New York State Psychiatric Institute United States
- University Physicians United States
Adult, Male, Depressive Disorder, Major, Pyridines, Middle Aged, Antidepressive Agents, Piperazines, Treatment Outcome, Predictive Value of Tests, Receptor, Serotonin, 5-HT1A, Linear Models, Humans, Female, Follow-Up Studies, Protein Binding
Adult, Male, Depressive Disorder, Major, Pyridines, Middle Aged, Antidepressive Agents, Piperazines, Treatment Outcome, Predictive Value of Tests, Receptor, Serotonin, 5-HT1A, Linear Models, Humans, Female, Follow-Up Studies, Protein Binding
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