Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease
Copyright policy )Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease
The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.
- University of Milan Italy
Aged, 80 and over, Male, Receptor, Adenosine A2A, adenosine receptors; Alzheimer's disease; biomarker; vascular dementia, Dementia, Vascular, Alzheimer Disease, Leukocytes, Mononuclear, Humans, Cognitive Dysfunction, Female, RNA, Messenger, Aged
Aged, 80 and over, Male, Receptor, Adenosine A2A, adenosine receptors; Alzheimer's disease; biomarker; vascular dementia, Dementia, Vascular, Alzheimer Disease, Leukocytes, Mononuclear, Humans, Cognitive Dysfunction, Female, RNA, Messenger, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).16 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!