Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter
Copyright policy )Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter
The expression of insulin-like growth factor I (IGF-I) is regulated by hormones, oncogenes, and other growth factors, and is markedly decreased or even absent in senescent human diploid fibroblasts. In previous articles, we have reported that the SV40 large T antigen increases the production of IGF-I and that the expression of the IGF-I gene is negatively regulated by an E2F binding site in the IGF-I promoter. We have now investigated the activity of the IGF-I promoter, in response to stimulation of cells by either PDGF or EGF. Both growth factors stimulate the activity of the IGF-I promoter, indicating that they regulate the levels of expression of IGF-I. When the E2F binding sequence in the IGF-I promoter is mutated, the IGF-I promoter is constitutively active and no longer responds to the action of growth factors.
- Thomas Jefferson University United States
Chloramphenicol O-Acetyltransferase, Platelet-Derived Growth Factor, Base Sequence, Epidermal Growth Factor, Molecular Sequence Data, Cell Cycle Proteins, 3T3 Cells, E2F Transcription Factors, Rats, DNA-Binding Proteins, Mice, Mutation, Animals, Humans, Insulin-Like Growth Factor I, Carrier Proteins, Promoter Regions, Genetic, Transcription Factor DP1, Retinoblastoma-Binding Protein 1, Transcription Factors
Chloramphenicol O-Acetyltransferase, Platelet-Derived Growth Factor, Base Sequence, Epidermal Growth Factor, Molecular Sequence Data, Cell Cycle Proteins, 3T3 Cells, E2F Transcription Factors, Rats, DNA-Binding Proteins, Mice, Mutation, Animals, Humans, Insulin-Like Growth Factor I, Carrier Proteins, Promoter Regions, Genetic, Transcription Factor DP1, Retinoblastoma-Binding Protein 1, Transcription Factors
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