A Novel Cyclin Gene (CCNF) in the Region of the Polycystic Kidney Disease Gene (PKD1)
Copyright policy )A Novel Cyclin Gene (CCNF) in the Region of the Polycystic Kidney Disease Gene (PKD1)
The major locus for autosomal dominant polycystic kidney disease (PKD1) is located in a gene-rich region on chromosome 16p13.3. Recently the identification of the gene responsible for PKD1 has been described. While searching for candidate genes in this region, we isolated a new member of the cyclin family. We have characterized the transcript by sequencing, determination of the exon intron boundaries, and Northern blot analysis. Cyclin F is related to A- and B-type cyclins by sequence, but its function is unknown.
- Brigham and Women's Faulkner Hospital United States
- Johns Hopkins University United States
DNA, Complementary, TRPP Cation Channels, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Proteins, Polycystic Kidney, Autosomal Dominant, Cyclins, Humans, Amino Acid Sequence, Chromosomes, Human, Pair 16
DNA, Complementary, TRPP Cation Channels, Base Sequence, Molecular Sequence Data, Chromosome Mapping, Proteins, Polycystic Kidney, Autosomal Dominant, Cyclins, Humans, Amino Acid Sequence, Chromosomes, Human, Pair 16
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