Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis
Copyright policy )Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis
Key PointsA Cdk6 R31C knock-in mutation resistant to INK4 inhibitors cooperates with Cdk4 hyperactivity in the development of hematopoietic tumors. In Cdk6 R31C cells, p16INK4a increasingly binds and inhibits Cdk4, suggesting that both kinases cooperate in sequestering INK4 proteins in cancer.
- Spanish National Cancer Research Centre Spain
- University of Bordeaux France
- University of Vienna Austria
- Instituto de Salud Carlos III Spain
- University of Bordeaux France
Cell Death, Carcinogenesis, Fusion Proteins, bcr-abl, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Hematopoietic Stem Cells, Hematopoiesis, Mice, Gene Ontology, Animals, Mutant Proteins, Alleles, Cell Line, Transformed, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor Proteins
Cell Death, Carcinogenesis, Fusion Proteins, bcr-abl, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Hematopoietic Stem Cells, Hematopoiesis, Mice, Gene Ontology, Animals, Mutant Proteins, Alleles, Cell Line, Transformed, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor Proteins
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