The HHEX gene is not related to congenital heart disease in 296 Chinese patients
Copyright policy )The HHEX gene is not related to congenital heart disease in 296 Chinese patients
The hematopoietically expressed homeobox (HHEX) gene is an important determinant of mammalian heart development. This study aimed to identify the potential mutations of the gene in Chinese patients with congenital heart disease (CHD).We collected 296 CHD patients and 200 controls, and classified the cardiac deformities. Then we conducted sequence analyses of the HHEX gene in those patients.In all the CHD patients, we did not find any causative mutations in the coding region of the HHEX gene.To our knowledge, this is the first study to examine the HHEX gene in non-symptomatic CHD cases, and this has expanded our knowledge about its etiology.
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- First Hospital of China Medical University China (People's Republic of)
- World Health Organization Switzerland
- China Medical University China (People's Republic of)
Heart Defects, Congenital, Homeodomain Proteins, Asian People, Mutation, Humans, Child, Transcription Factors
Heart Defects, Congenital, Homeodomain Proteins, Asian People, Mutation, Humans, Child, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!