Association of the leukemia inhibitory factor gene polymorphism rs929271 with idiopathic mild intellectual disability
Copyright policy )Association of the leukemia inhibitory factor gene polymorphism rs929271 with idiopathic mild intellectual disability
????????. ?????????????????????? ?????????????????? ???????????????????? ?????????????????????????? rs929271 ???????? LIF ?? ???????????? ???????????????????????????????? ???????????????????????????????????????? (????). ????????????. ???????????? ?????????????????? ?? ???????????? (IQ ?????????? 50 ?? 70) ???????????????????????????? ???????????????????????????????? ?????????????????????????????????? ???????????????? ???? 64 ??????????????????, ?????????????? 40 (62,5 %) ???????????? ?? 24 (47,5 %) ??????????????. ?????????????????????? ???????????? ???????????????? ???? 238 ???????????????? ???????????????????????? ???? ???????????? ???????????????? ??????????????. ?????????????????????? ???????????????? rs929271 ???????? LIF ???????????????? ?????????????????????? ?????? ?? ?????????????????????? Hinf1 ???????? ????????????????. ????????????????????. ???????? ???????????????? ???????????? ?? ?????????????????????????? ?????????????????? ?? ?????????????????? ?????????????????? ???????? LIF ?? ???????????? ?????????????????? ?? ???? ?? ?? ?????????????????????? ????????????. ???????????????????????????? ???????????? ???????????????????? ???????????????? ???????????????? ???? rs929271 ?????? ?????? ???????????? ??????????????????, ?????? ?? ?????????????? ?????? ?????????????????? ?????????????????????? ?? ?????????????????????? ?????????? (?? = 0,01 ?? 0,02, ????????????????????????????). ????????????. ???????? ???????????????????? ????????????????????, ?????? ?????????????????????? rs929271???????? LIF ???????????????????????? ?? ???????????? ???????????????????????????? ???????????????????????????????? ??????????????????????????????????. ?????????????? ???? ???????????????????? LIF ?? ???????????????? ???????????? ?????????????? ???????????????????????? ?????????????????????????????????????? ?? ???????????????????????????????? ????????????????????????????????.
????????. ?????????????????? ?????????????? ?????????????????? ???????????????????????? rs929271 ???????? LIF ?? ???????????? ?????????????????????????????? ???????????????????????????? (????). ????????????. ?????????? ?????????????????? ?? ???????????? (IQ ?????? 50 ?? 70) ???????????????????????? ?????????????????????????????? ???????????????????????????? ???????????????????? ?? 64 ??????????????????, ?????????????????? 40 (62,5 %) ?????????????????? ?? 24 (47,5 %) ??????????. ???????????????????? ?????????? ???????????????????? ?? 238 ???????????????? ???????????????????????? ?? ???????????? ???????????????? ??????????????. ???????????????????? ???????????????? rs929271 ???????? LIF ???????????????? ???? ?????????????????? ?????? ?? ?????????????????? Hinf1 ???????? ????????????????. ????????????????????. ???????? ???????????????? ???????? ?????? ???????????????? ?????????????????? ?? ???????????????? ?????????????????? ?????????? LIF ?? ?????????? ?????????????????? ?? ???? ?? ?? ?????????????????????? ??????????. ???????????????????????? ???????????? ?????????????? ?????????????? ?????????????????????? ???? rs929271 ???? ?????? ???????????? ??????????????????, ?????? ?? ???????????????? ?????????????????? ?????? ???????????????????? ?????????????????????????? ???? ?????????????????????? ???????? (?? = 0,01 ?? 0,02, ????????????????????). ????????????????. ???????? ???????????????????? ??????????????????, ???? ?????????????????????? rs929271???????? LIF ???????????????????????? ?? ???????????? ???????????????????????? ?????????????????????????????? ????????????????????????????. ???????? ???? ???????????????????? LIF ?? ???????????? ???????????? ?????????????? ???????????????????? ?????????????????????? ???? ?????????????????????????????? ????????????????????????????.
Aim. To investigate the possible association of LIF gene polymorphism rs929271 with mild intellectual disability (ID). Methods. The group of patients with mild (IQ score between 50 and 70) idiopathic intellectual disability consisted of 64 individuals including 40 (62.5 %) males and 24 (47.5 %) females. The control group consisted of 238 healthy volunteers from different regions of Ukraine. Polymorphic variants of LIF gene rs929271 were detected using PCR followed by Hinf1 RFLP analysis. Results. The data concerning LIF genotypes and allelic variants distribution in ID patients and control group were obtained. Statistical analysis shows significant differences at rs929271 for both genotype and allele frequency when comparing ID cases and controls (p = 0.01 and 0.02, respectively). Conclusions. Our results suggest that LIF gene polymorphism rs929271 is associated with idiopathic mild intellectual disability. Therefore, we propose LIF as a new marker of genetic susceptibility for intellectual disability.
Biomedicine
Biomedicine
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