The HSP90 family of genes in the human genome: Insights into their divergence and evolution
Copyright policy )The HSP90 family of genes in the human genome: Insights into their divergence and evolution
HSP90 proteins are important molecular chaperones. Transcriptome and genome analyses revealed that the human HSP90 family includes 17 genes that fall into four classes. A standardized nomenclature for each of these genes is presented here. Classes HSP90AA, HSP90AB, HSP90B, and TRAP contain 7, 6, 3, and 1 genes, respectively. HSP90AA genes mapped onto chromosomes 1, 3, 4, and 11; HSP90AB genes mapped onto 3, 4, 6, 13 and 15; HSP90B genes mapped onto 1, 12, and 15; and the TRAP1 gene mapped onto 16. Six genes, HSP90AA1, HSP90AA2, HSP90N, HSP90AB1, HSP90B1 and TRAP1, were recognized as functional, and the remaining 11 genes were considered putative pseudogenes. Amino acid polymorphic variants were detected for genes HSP90AA1, HSP90AA2, HSP90AB1, HSP90B1, and TRAP1. The structures of these genes and the functional motifs and polymorphic variants of their proteins were documented and the features and functions of their proteins were discussed. Phylogenetic analyses based on both nucleotide and protein data demonstrated that HSP90(AA+AB+B) formed a monophyletic clade, whereas TRAP is a relatively distant paralogue of this clade.
- University College London United Kingdom
- State University of New York at Potsdam United States
- University at Buffalo, State University of New York United States
- University of Leeds United Kingdom
Base Sequence, Genome, Human, Molecular Sequence Data, Chromosome Mapping, Computational Biology, Genomics, Sequence Analysis, DNA, Evolution, Molecular, Gene Components, Multigene Family, Genetics, Humans, Amino Acid Sequence, HSP90 Heat-Shock Proteins, Sequence Alignment, Phylogeny
Base Sequence, Genome, Human, Molecular Sequence Data, Chromosome Mapping, Computational Biology, Genomics, Sequence Analysis, DNA, Evolution, Molecular, Gene Components, Multigene Family, Genetics, Humans, Amino Acid Sequence, HSP90 Heat-Shock Proteins, Sequence Alignment, Phylogeny
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