Insulators and imprinting from flies to mammals
Copyright policy )Insulators and imprinting from flies to mammals
The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and that CTCF may also play a critical role in this process. See research article http://www.biomedcentral.com/1741-7007/8/105.
- Department of Biology United States
- Emory University United States
Mammals, Repressor Proteins, CCCTC-Binding Factor, Genomic Imprinting, Drosophila melanogaster, Agricultural and Biological Sciences(all), Models, Genetic, QH301-705.5, Biochemistry, Genetics and Molecular Biology(all), Commentary, Animals, Drosophila Proteins, Biology (General)
Mammals, Repressor Proteins, CCCTC-Binding Factor, Genomic Imprinting, Drosophila melanogaster, Agricultural and Biological Sciences(all), Models, Genetic, QH301-705.5, Biochemistry, Genetics and Molecular Biology(all), Commentary, Animals, Drosophila Proteins, Biology (General)
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