TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling
Copyright policy )TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling
AbstractTransmembrane p24 trafficking protein 3(TMED3) is a metastatic suppressor in colon cancer, but its function in the progression of hepatocellular carcinoma (HCC) is unknown. Here, we report that TMED3 was up-regulated in HCC and portal vein tumor thrombus. TMED3 up-regulation in HCC was significantly correlated with aggressive characteristics and predicted poor prognosis in HCC patients. TMED3 overexpression in HCC cell lines promoted cell migration and invasion. In contrast, TMED3 knockdown suppressed HCC metastasis both in vitro and in vivo. Gene microarray analysis revealed decreased IL-11 expression in TMED3-knockdown cells. We propose that TMED3 promotes HCC metastasis through IL-11/STAT3 signaling. Taken together, these findings demonstrate that TMED3 promotes HCC metastasis and is a potential prognostic biomarker in HCC.
- Second Military Medical University China (People's Republic of)
- Eastern Hepatobiliary Surgery Hospital China (People's Republic of)
- Nanjing General Hospital of Nanjing Military Command China (People's Republic of)
- Shanghai Jiao Tong University China (People's Republic of)
- Changhai Hospital China (People's Republic of)
Male, STAT3 Transcription Factor, Mice, Inbred BALB C, Carcinoma, Hepatocellular, Liver Neoplasms, Vesicular Transport Proteins, Mice, Nude, Middle Aged, Interleukin-11, Article, Up-Regulation, Gene Expression Regulation, Neoplastic, Cell Movement, Gene Knockdown Techniques, Disease Progression, Animals, Humans, Female, Neoplasm Metastasis
Male, STAT3 Transcription Factor, Mice, Inbred BALB C, Carcinoma, Hepatocellular, Liver Neoplasms, Vesicular Transport Proteins, Mice, Nude, Middle Aged, Interleukin-11, Article, Up-Regulation, Gene Expression Regulation, Neoplastic, Cell Movement, Gene Knockdown Techniques, Disease Progression, Animals, Humans, Female, Neoplasm Metastasis
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