Homologs of Drosophila fushi-tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33
Copyright policy )Homologs of Drosophila fushi-tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33
SF-1, a nuclear receptor that regulates gene expression of the cytochrome P450 steroid hydroxylases, and ELP, an embryonal protein that suppresses expression of the Moloney murine leukemia virus LTR, are isoforms transcribed from the same gene by alternative promoter usage and splicing. This gene is the mammalian homolog of the Drosophila fushi-tarazu factor 1 (FTZ-F1) gene. We have mapped the mouse gene Ftzf1 to the proximal quarter of Chr 2 by a linkage analysis using interspecific backcross mice, and its human homolog FTZ1 to Chr 9q33 by fluorescence in situ hybridization. The mouse and human genes are located in the homologous regions of mouse Chr 2 and human Chr 9, respectively.
- Hiroshima University Japan
- Brigham and Women's Faulkner Hospital United States
- University of Salford United Kingdom
- Duke University United States
- Duke University Hospital United States
Cytoplasmic and Nuclear, Genetic Linkage, RNA Splicing, Research Support, U.S. Gov't, P.H.S., Fushi Tarazu Transcription Factors, Receptors, Cytoplasmic and Nuclear, Research Support, P.H.S., Steroidogenic Factor 1, Chromosomes, Fluorescence, Promoter Regions, Mice, Genetic, Receptors, Journal Article, Animals, Humans, Non-U.S. Gov't, Promoter Regions, Genetic, In Situ Hybridization, In Situ Hybridization, Fluorescence, Homeodomain Proteins, Mice, Inbred C3H, Research Support, Non-U.S. Gov't, Chromosome Mapping, Inbred C3H, DNA-Binding Proteins, Repressor Proteins, U.S. Gov't, Chromosomes, Human, Pair 9, Human, Pair 9, Adrenal Insufficiency, Transcription Factors
Cytoplasmic and Nuclear, Genetic Linkage, RNA Splicing, Research Support, U.S. Gov't, P.H.S., Fushi Tarazu Transcription Factors, Receptors, Cytoplasmic and Nuclear, Research Support, P.H.S., Steroidogenic Factor 1, Chromosomes, Fluorescence, Promoter Regions, Mice, Genetic, Receptors, Journal Article, Animals, Humans, Non-U.S. Gov't, Promoter Regions, Genetic, In Situ Hybridization, In Situ Hybridization, Fluorescence, Homeodomain Proteins, Mice, Inbred C3H, Research Support, Non-U.S. Gov't, Chromosome Mapping, Inbred C3H, DNA-Binding Proteins, Repressor Proteins, U.S. Gov't, Chromosomes, Human, Pair 9, Human, Pair 9, Adrenal Insufficiency, Transcription Factors
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