An 8-week-old girl, born at term, was referred for systematic evaluation1 of tuberous sclerosis complex prenatally revealed by cardiac rhabdomyomas. No clinical seizures were reported. Video-EEG revealed normal background in sleep and wake, no epileptic discharges, but focal rhythmic slow spikes and waves in the left temporal area (figure 1) predominantly during sleep. Brain MRI performed 3 hours after the EEG recording showed subependymal nodules and brain tubers. Arterial spin labeling imaging showed left temporal hyperperfusion corresponding to a tuber (figure 2). This case illustrates an unusual correlation between “pre-epileptic” EEG findings and tuber-limited hyperperfusion during systematic screening of an infant with prenatal diagnosis of tuberous sclerosis complex. Acknowledgment: The authors thank the patient and her parents who gave their consent for the publication of this medical report.