Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity
Copyright policy )Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity
Key PointsAdenosine signaling via ADORA2B induces SphK1 activity in sickle and normal erythrocytes via PKA-mediated ERK1/2 activation. Lowering adenosine by PEG-ADA or interfering ADORA2B activation by specific antagonist decreases SphK1 activity in normal and sickle RBCs.
- The University of Texas System United States
- The University of Texas Health Science Center at Houston United States
Mice, Knockout, Adenosine, Erythrocytes, Adenosine Deaminase, MAP Kinase Signaling System, Hemoglobin, Sickle, Erythrocytes, Abnormal, Mice, Transgenic, Adenosine-5'-(N-ethylcarboxamide), Anemia, Sickle Cell, Receptor, Adenosine A2B, Cyclic AMP-Dependent Protein Kinases, Models, Biological, Mice, Phosphotransferases (Alcohol Group Acceptor), Agammaglobulinemia, Animals, Humans, Severe Combined Immunodeficiency, Cells, Cultured
Mice, Knockout, Adenosine, Erythrocytes, Adenosine Deaminase, MAP Kinase Signaling System, Hemoglobin, Sickle, Erythrocytes, Abnormal, Mice, Transgenic, Adenosine-5'-(N-ethylcarboxamide), Anemia, Sickle Cell, Receptor, Adenosine A2B, Cyclic AMP-Dependent Protein Kinases, Models, Biological, Mice, Phosphotransferases (Alcohol Group Acceptor), Agammaglobulinemia, Animals, Humans, Severe Combined Immunodeficiency, Cells, Cultured
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