Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart
Copyright policy )Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart
With the aim of identifying genes involved in human heart development and disease, we have isolated a novel KRAB-related zinc-finger gene named ZNF382 from heart cDNA library. The ZNF382 gene has a predicted 548-amino acid open reading frame, encoding a putative 64kDa zinc-finger protein. The N-terminus of the ZNF382 coding region has a well-conserved Krüpple-associated box domain that consists of KRAB boxes A and B, whereas the C-terminus contains a Krüpple-type zinc-finger domain possessing nine C(2)H(2) zinc-finger motifs in tandem arrays. The ZNF382 gene is mapped to chromosome 19q13.13. Northern blot analysis indicates that a 2.9-kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day) and widely in human embryo tissues. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.
- The University of Texas System United States
- Hunan Normal University China (People's Republic of)
- Texas A&M University System United States
Myocardium, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Gene Expression Regulation, Developmental, Heart, Zinc Fingers, Embryo, Mammalian, Protein Structure, Tertiary, Rats, DNA-Binding Proteins, Fetal Heart, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Chromosomes, Human, Pair 19, Sequence Alignment, Phylogeny, Transcription Factors
Myocardium, Molecular Sequence Data, Chromosome Mapping, Gene Expression, Gene Expression Regulation, Developmental, Heart, Zinc Fingers, Embryo, Mammalian, Protein Structure, Tertiary, Rats, DNA-Binding Proteins, Fetal Heart, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Chromosomes, Human, Pair 19, Sequence Alignment, Phylogeny, Transcription Factors
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