Prothrombotic SERPINC1 Gene Polymorphism may Affect Heparin Sensitivity Among Different Ethnicities of Chinese Patients Receiving Heart Surgery
Copyright policy )Prothrombotic SERPINC1 Gene Polymorphism may Affect Heparin Sensitivity Among Different Ethnicities of Chinese Patients Receiving Heart Surgery
The purpose of this study was to investigate a possible correlation between single-nucleotide polymorphisms (SNPs) of the antithrombin (gene, SERPINC1, and perioperative sensitivity to heparin in patients receiving heart surgery. The SERPINC1 genotype and allele frequency, coagulation parameters 24 hours before and after surgery, and clinical findings were compared among 3 ethnic groups, Han, Uighur, and Kazakh, patientswho received heart surgery. In Han patients, longer coagulation time as well as higher heparin and protamine dosage was observed. SERPINC1 gene sequencing identified 2 mutations in exon 5, g.981A>G (rs5877) and g.1011A>G (rs5878). The minor allele frequency of allele (A>G) for rs5877 and rs5878 was higher in the Han patients and was significantly different among the ethnic groups ( P = .004 and P = .006, respectively). The increased SERPINC1 SNP frequency among Han patients receiving heart surgery might contribute to the differences in their perioperative sensitivity to heparin.
- First Affiliated Hospital of Anhui Medical University China (People's Republic of)
- First Affiliated Hospital of Xinjiang Medical University China (People's Republic of)
Adult, Male, China, Heparin, Middle Aged, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Heparin Cofactor II, Humans, Female, Cardiac Surgical Procedures, Blood Coagulation, Alleles
Adult, Male, China, Heparin, Middle Aged, Polymorphism, Single Nucleotide, Asian People, Gene Frequency, Heparin Cofactor II, Humans, Female, Cardiac Surgical Procedures, Blood Coagulation, Alleles
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