5-HT 2C receptors are involved in the discriminative stimulus effects of citalopram in rats
Copyright policy )5-HT 2C receptors are involved in the discriminative stimulus effects of citalopram in rats
Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopram with an ED50 of 0.3 mg/kg, IP. Further, the selective 5-HT2C receptor antagonist, SB242,084, dose-dependently (ED50=0.1 mg/kg, IP) blocked the citalopram DS. These data suggest that 5-HT2C receptors are involved in the DS properties of the SSRI, citalopram, in rats. They do not, however, exclude a potential role of other 5-HT receptor types.
Discrimination Learning, Male, Dose-Response Relationship, Drug, Receptors, Serotonin, Receptor, Serotonin, 5-HT2C, Animals, Citalopram, Rats, Wistar, Selective Serotonin Reuptake Inhibitors, Rats
Discrimination Learning, Male, Dose-Response Relationship, Drug, Receptors, Serotonin, Receptor, Serotonin, 5-HT2C, Animals, Citalopram, Rats, Wistar, Selective Serotonin Reuptake Inhibitors, Rats
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