Matrix metalloproteinases-1 and -2, and tissue inhibitor of metalloproteinase-2 production is abnormal in bone marrow stromal cells of multiple myeloma patients
Copyright policy )Matrix metalloproteinases-1 and -2, and tissue inhibitor of metalloproteinase-2 production is abnormal in bone marrow stromal cells of multiple myeloma patients
We have investigated the production of metalloproteinases (MMP-1, MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) and a healthy control. The new findings of this paper is that BMSCs of the MM patients exhibited intrinsic MMP-1, MMP-2 and TIMP-2 overproduction. Production of MMP-1, TIMP-2 and activation of MMP-2 was additionally enhanced in co-cultures of BMSCs with RPMI8226 cells. The ratio between MMP-2 and TIMP-2 was significantly higher in BMSCs of the MM patients than in control. BMSCs of both the control and the MM patients exhibited the presence of MMP-9 latent form, but in co-cultures RPMI8226 cells were the main producers of this metalloproteinase.
Aged, 80 and over, Male, Tissue Inhibitor of Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-1, Bone Marrow Cells, Middle Aged, Coculture Techniques, Matrix Metalloproteinase 9, Tumor Cells, Cultured, Humans, Matrix Metalloproteinase 2, Female, Matrix Metalloproteinase 1, Stromal Cells, Multiple Myeloma, Aged
Aged, 80 and over, Male, Tissue Inhibitor of Metalloproteinase-2, Tissue Inhibitor of Metalloproteinase-1, Bone Marrow Cells, Middle Aged, Coculture Techniques, Matrix Metalloproteinase 9, Tumor Cells, Cultured, Humans, Matrix Metalloproteinase 2, Female, Matrix Metalloproteinase 1, Stromal Cells, Multiple Myeloma, Aged
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