Dynamics of Cell Shape Inheritance in Fission Yeast
pmid: 25210736
pmc: PMC4161360
Dynamics of Cell Shape Inheritance in Fission Yeast
Every cell has a characteristic shape key to its fate and function. That shape is not only the product of genetic design and of the physical and biochemical environment, but it is also subject to inheritance. However, the nature and contribution of cell shape inheritance to morphogenetic control is mostly ignored. Here, we investigate morphogenetic inheritance in the cylindrically-shaped fission yeast Schizosaccharomyces pombe. Focusing on sixteen different 'curved' mutants--a class of mutants which often fail to grow axially straight--we quantitatively characterize their dynamics of cell shape inheritance throughout generations. We show that mutants of similar machineries display similar dynamics of cell shape inheritance, and exploit this feature to show that persistent axial cell growth in S. pombe is secured by multiple, separable molecular pathways. Finally, we find that one of those pathways corresponds to the swc2-swr1-vps71 SWR1/SRCAP chromatin remodelling complex, which acts additively to the known mal3-tip1-mto1-mto2 microtubule and tea1-tea2-tea4-pom1 polarity machineries.
- University of Bristol United Kingdom
- University of Cambridge United Kingdom
- Wellcome Trust United Kingdom
- Cancer Research UK United Kingdom
- THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom
570, Science, Q, R, 500, Cell Polarity, Research Support, Chromatin Assembly and Disassembly, Microtubules, Protein Transport, Mutation, Schizosaccharomyces, Journal Article, Medicine, Non-U.S. Gov't, Cell Shape, Metabolic Networks and Pathways, Research Article
570, Science, Q, R, 500, Cell Polarity, Research Support, Chromatin Assembly and Disassembly, Microtubules, Protein Transport, Mutation, Schizosaccharomyces, Journal Article, Medicine, Non-U.S. Gov't, Cell Shape, Metabolic Networks and Pathways, Research Article
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