The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
Copyright policy )The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN). We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior. These mice also fail to exhibit circadian expression of the core clock genes mPer1, mPer2, and mCry1 and the clock-controlled gene arginine vasopressin (AVP) in the SCN. Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN.
- University of Salford United Kingdom
- NHS Lothian United Kingdom
- University of Edinburgh United Kingdom
- University of Bern Switzerland
- MRC Laboratory of Molecular Biology United Kingdom
Male, Mice, Knockout, Neurons, Neurophysins, Flavoproteins, Biochemistry, Genetics and Molecular Biology(all), Neuropeptides, ARNTL Transcription Factors, Cell Cycle Proteins, Motor Activity, Circadian Rhythm, Arginine Vasopressin, Cryptochromes, Mice, Gene Expression Regulation, Biological Clocks, Mutation, Basic Helix-Loop-Helix Transcription Factors, Animals, Drosophila Proteins, Eye Proteins
Male, Mice, Knockout, Neurons, Neurophysins, Flavoproteins, Biochemistry, Genetics and Molecular Biology(all), Neuropeptides, ARNTL Transcription Factors, Cell Cycle Proteins, Motor Activity, Circadian Rhythm, Arginine Vasopressin, Cryptochromes, Mice, Gene Expression Regulation, Biological Clocks, Mutation, Basic Helix-Loop-Helix Transcription Factors, Animals, Drosophila Proteins, Eye Proteins
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