Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL
Copyright policy )Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL
Key PointsPrenatal platelet-forming lineages are subject to common transcription factor controls despite distinct spatial and ancestral origins. Platelet-forming lineage production is MPL-independent on emergence, but MPL is required in the late fetus for efficient thrombopoiesis.
- University of Melbourne Australia
- Walter and Eliza Hall Institute of Medical Research Australia
Blood Platelets, Mice, Knockout, Transcription, Genetic, Embryonic Development, Gene Expression Regulation, Developmental, Cell Differentiation, Hematopoietic Stem Cells, Thrombopoiesis, Mice, NF-E2 Transcription Factor, p45 Subunit, Animals, Cell Lineage, GATA1 Transcription Factor, Megakaryocytes, Receptors, Thrombopoietin, Gene Deletion, Yolk Sac
Blood Platelets, Mice, Knockout, Transcription, Genetic, Embryonic Development, Gene Expression Regulation, Developmental, Cell Differentiation, Hematopoietic Stem Cells, Thrombopoiesis, Mice, NF-E2 Transcription Factor, p45 Subunit, Animals, Cell Lineage, GATA1 Transcription Factor, Megakaryocytes, Receptors, Thrombopoietin, Gene Deletion, Yolk Sac
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