Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
Copyright policy )Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
Abstract The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1 , which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
- Kyoto University Japan
- Department of Neuroscience Karolinska Institutet Sweden
- Boston University United States
- McGill University Canada
- University of Edinburgh, The Roslin Institute United Kingdom
2',5'-Oligoadenylate Synthetase/genetics, RNA Splicing, Black People, COVID-19, Brief Communication, Physical Chromosome Mapping, Severity of Illness Index, Linkage Disequilibrium, White People, COVID-19/enzymology, Risk Factors, Blacks/genetics, 2',5'-Oligoadenylate Synthetase, Humans, Linkage Disequilibrium/genetics, Genetic Predisposition to Disease, RNA Splicing/genetics, Whites/genetics
2',5'-Oligoadenylate Synthetase/genetics, RNA Splicing, Black People, COVID-19, Brief Communication, Physical Chromosome Mapping, Severity of Illness Index, Linkage Disequilibrium, White People, COVID-19/enzymology, Risk Factors, Blacks/genetics, 2',5'-Oligoadenylate Synthetase, Humans, Linkage Disequilibrium/genetics, Genetic Predisposition to Disease, RNA Splicing/genetics, Whites/genetics
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