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The Small Interfering RNA Pathway Is Not Essential for Wolbachia-Mediated Antiviral Protection in Drosophila melanogaster

descriptionPublicationkeyboard_double_arrow_right Article 15 Sep 2012 Australia English Publisher:American Society for MicrobiologyJournal:Applied and Environmental Microbiology, volume 78, pages 6,773-6,776 (issn: 0099-2240, eissn: 1098-5336,

Authors: Hedges, Lauren M.; Yamada, Ryuichi; O'Neill, Scott L.; Johnson, Karyn N.;

doi: 10.1128/aem.01650-12

pmid: 22798369

pmc: PMC3426675

The Small Interfering RNA Pathway Is Not Essential for Wolbachia-Mediated Antiviral Protection in Drosophila melanogaster

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Abstract

ABSTRACT Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia -mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense. Compared to Wolbachia -free flies, virus-induced mortality was delayed in Wolbachia -infected flies with loss-of-function of siRNA pathway components, indicating that Wolbachia -mediated protection functions in the absence of the canonical siRNA pathway.

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Australia

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Keywords

Immunity, Distinct roles, Survival Analysis, Drosophila melanogaster, 1305 Biotechnology, 2402 Applied Microbiology and Biotechnology, Animals, RNA Viruses, RNA, Small Interfering, Host defense, Infection, 2303 Ecology, 1106 Food Science, Metabolic Networks and Pathways, Wolbachia

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