Localization of the gene for the trans-acting transcription factor Sp1 to the distal end of mouse chromosome 15
Copyright policy )Localization of the gene for the trans-acting transcription factor Sp1 to the distal end of mouse chromosome 15
The mouse chromosomal location for the gene (Sp1-1) encoding the trans-acting transcription factor Sp1 has been determined. Analysis of restriction fragment length polymorphisms in recombinant inbred, congenic, and interspecific backcross mice using human and mouse cDNA probes demonstrated that Sp1-1 is a single gene closely linked to the mammary tumor virus integration site-1 (Int-1) on the distal end of chromosome 15. Sp1 is a zinc finger protein, but Sp1-1 is not closely linked to any of the other zinc finger protein genes that have been mapped in mouse. Int-1 and other markers flanking the Sp1-1 locus are part of a conserved linkage group represented on human chromosome 12q.
- Jackson Laboratory United States
Muridae: ge, Genetic Markers, Male, Species-Specificity, Genetic Linkage, Sp1 Transcription Factor, Zinc-Fingers, 610, Transcription-Factor-Sp1: ge, Mice, Inbred Strains, Recombination-Genetic, DNA: ge, Linkage-(Genetics), Mice, Comparative-Study, Species Specificity, 616, Mice: ge, Animals, Humans, SUPPORT-NON-U-S-GOVT, Crosses, Genetic, Recombination, Genetic, Genes-Structural, Genetic-Markers, Chromosome Mapping, Crosses-Genetic, Zinc Fingers, DNA, Muridae, Genes, Chromosome-Mapping, Female, Mice-Inbred-Strains: ge, Restriction-Fragment-Length-Polymorphisms, Polymorphism, Restriction Fragment Length, Human
Muridae: ge, Genetic Markers, Male, Species-Specificity, Genetic Linkage, Sp1 Transcription Factor, Zinc-Fingers, 610, Transcription-Factor-Sp1: ge, Mice, Inbred Strains, Recombination-Genetic, DNA: ge, Linkage-(Genetics), Mice, Comparative-Study, Species Specificity, 616, Mice: ge, Animals, Humans, SUPPORT-NON-U-S-GOVT, Crosses, Genetic, Recombination, Genetic, Genes-Structural, Genetic-Markers, Chromosome Mapping, Crosses-Genetic, Zinc Fingers, DNA, Muridae, Genes, Chromosome-Mapping, Female, Mice-Inbred-Strains: ge, Restriction-Fragment-Length-Polymorphisms, Polymorphism, Restriction Fragment Length, Human
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