Involvement of headless myosin X in the motility of immortalized gonadotropin‐releasing hormone neuronal cells
Copyright policy )Involvement of headless myosin X in the motility of immortalized gonadotropin‐releasing hormone neuronal cells
AbstractMyosin X (Myo X), an unconventional myosin with a tail homology 4‐band 4.1/ezrin/radixin/moesin (MyTH4‐FERM) tail, is expressed ubiquitously in various mammalian tissues. In addition to the full‐length Myo X (Myo X FL), a headless form is synthesized in the brain. So far, little is known about the function of this motor‐less Myo X. In this study, the role of the headless Myo X was investigated in immortalized gonadotropin‐releasing hormone (GnRH) neuronal cells, NLT. NLT cells overexpressing the headless Myo X formed fewer focal adhesions and spread more slowly than the wild‐type NLT cells and GFP‐expressing NLT cells. In chemomigration assays, the NLT cells overexpressing the headless Myo X migrated shorter distances and had fewer migratory cells compared with the control NLT cells.
- Georgia Regents University United States
- Northeast Normal University China (People's Republic of)
Gonadotropin-Releasing Hormone, Neurons, Mice, Cell Movement, Recombinant Fusion Proteins, Cell Adhesion, Animals, Myosins, Cell Line
Gonadotropin-Releasing Hormone, Neurons, Mice, Cell Movement, Recombinant Fusion Proteins, Cell Adhesion, Animals, Myosins, Cell Line
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