γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease
Copyright policy )γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease
Tactical Target Intramembrane proteolysis by the γ-secretase complex is important during development and in the pathology of Alzheimer's disease. γ-Secretase has usually been considered as a homogeneous activity. Serneels et al. (p. 639 , published online 19 March; see the Perspective by Golde and Kukar ) now show that the Aph1B component of the γ-secretase complex is responsible for the generation of long β-amyloid species involved in Alzheimer's disease. In a mouse model of Alzheimer's disease, full knockout of Aph1B improved disease phenotypes, without the sort of toxicity previously observed when targeting γ-secretase more generally.
- Harvard University United States
- University of Erlangen-Nuremberg Germany
- Phillips University United States
- Centre For Human Genetics India
- Hertie Institute for Clinical Brain Research Germany
Neurons, Amyloid beta-Peptides, Brain, Membrane Proteins, Peptide Fragments, Amyloid beta-Protein Precursor, Disease Models, Animal, Mice, Protein Subunits, Alzheimer Disease, Memory, Endopeptidases, Presenilin-1, Animals, Humans, Female, Amyloid Precursor Protein Secretases, Receptor, Notch1, Maze Learning, Peptide Hydrolases
Neurons, Amyloid beta-Peptides, Brain, Membrane Proteins, Peptide Fragments, Amyloid beta-Protein Precursor, Disease Models, Animal, Mice, Protein Subunits, Alzheimer Disease, Memory, Endopeptidases, Presenilin-1, Animals, Humans, Female, Amyloid Precursor Protein Secretases, Receptor, Notch1, Maze Learning, Peptide Hydrolases
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