Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver
Copyright policy )Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver
The mouse H-2 multigene family includes the genes coding for the major transplantation antigens and for genes located in the Qa-TIa region. We have studied a collection of class I cDNA clones made from liver mRNA of DBA/2 mice (H-2d haplotype) and found that at least six distinct class I genes are transcribed, including three genes of the Qa-TIa region. Two of these six genes each yield two distinct mRNAs, resulting from alternate splicing. Altogether, liver cells may express at least eight distinct class I polypeptides, of which three might be secreted, while one may be a new presumptive nonpolymorphic surface antigen.
- Institut Pasteur France
Base Sequence, Transcription, Genetic, RNA Splicing, H-2 Antigens, Chromosome Mapping, Nucleic Acid Hybridization, DNA, Major Histocompatibility Complex, Mice, Genes, Liver, Mice, Inbred DBA, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
Base Sequence, Transcription, Genetic, RNA Splicing, H-2 Antigens, Chromosome Mapping, Nucleic Acid Hybridization, DNA, Major Histocompatibility Complex, Mice, Genes, Liver, Mice, Inbred DBA, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular
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