Leukotriene C4 Synthase A‐444C Gene Polymorphism in Patients with Allergic Rhinitis
Copyright policy )Leukotriene C4 Synthase A‐444C Gene Polymorphism in Patients with Allergic Rhinitis
OBJECTIVETo determine the frequency of leukotriene C4 synthase A‐444C polymorphism in allergic rhinitis patients.STUDY DESIGN AND SETTINGA prospective, randomized, case‐controlled study. Blood samples were obtained from 85 patients with allergic rhinitis and 95 healthy individuals. After the extraction of DNA from the blood samples, the leukotriene C4 synthase A‐444C polymorphism was studied by a real‐time polymerase chain reaction method.RESULTSThe AC and CC genotype frequencies were statistically higher in the study group (P = 0.048 and P = 0.037, respectively). In addition, the AC polymorphism carried an increased risk of developing allergic rhinitis (odds ratio = 2.18, 95% confidence interval, 1.173–4.053, P = 0.014).CONCLUSIONThe C allele of the leukotriene C4 synthase gene increases the risk of developing allergic rhinitis.SIGNIFICANCEThe leukotriene C4 synthase A‐444C gene polymorphism is important in susceptibility to allergic rhinitis and this is the first study of this gene polymorphism in allergic rhinitis.
- Mersin University Turkey
Adult, Male, Polymorphism, Genetic, Rhinitis, Allergic, Seasonal, Immunoglobulin E, Polymerase Chain Reaction, Intracellular Calcium-Sensing Proteins, Gene Frequency, Case-Control Studies, Humans, Female, Mast Cells, Prospective Studies, Glutathione Transferase, Randomized Controlled Trials as Topic
Adult, Male, Polymorphism, Genetic, Rhinitis, Allergic, Seasonal, Immunoglobulin E, Polymerase Chain Reaction, Intracellular Calcium-Sensing Proteins, Gene Frequency, Case-Control Studies, Humans, Female, Mast Cells, Prospective Studies, Glutathione Transferase, Randomized Controlled Trials as Topic
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