Regulator of G Protein Signaling 1 Suppresses CXCL12-Mediated Migration and AKT Activation in RPMI 8226 Human Plasmacytoma Cells and Plasmablasts
Copyright policy )Regulator of G Protein Signaling 1 Suppresses CXCL12-Mediated Migration and AKT Activation in RPMI 8226 Human Plasmacytoma Cells and Plasmablasts
Migration of plasma cells to the bone marrow is critical factor to humoral immunity and controlled by chemokines. Regulator of G protein signaling 1 (RGS1) is a GTPase-activating protein that controls various crucial functions such as migration. Here, we show that RGS1 controls the chemotactic migration of RPMI 8226 human plasmacytoma cells and human plasmablasts. LPS strongly increased RGS1 expression and retarded the migration of RPMI 8226 cells by suppressing CXCL12-mediated AKT activation. RGS1 knockdown by siRNA abolished the retardation of migration and AKT suppression by LPS. RGS1-dependent regulation of migration via AKT is also observed in cultured plasmablasts. We propose novel functions of RGS1 that suppress AKT activation and the migration of RPMI 8226 cells and plasmablasts in CXCL12-mediated chemotaxis.
- University of Ulsan Korea (Republic of)
- Asan Medical Center Korea (Republic of)
- Asan Foundation Korea (Republic of)
Lipopolysaccharides, Science, Chemotaxis, Q, Plasma Cells, R, Chemokine CXCL12, Gene Expression Regulation, Tumor Cells, Cultured, Medicine, Humans, RNA, Small Interfering, Proto-Oncogene Proteins c-akt, RGS Proteins, Research Article, Plasmacytoma, Signal Transduction
Lipopolysaccharides, Science, Chemotaxis, Q, Plasma Cells, R, Chemokine CXCL12, Gene Expression Regulation, Tumor Cells, Cultured, Medicine, Humans, RNA, Small Interfering, Proto-Oncogene Proteins c-akt, RGS Proteins, Research Article, Plasmacytoma, Signal Transduction
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