Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation
Copyright policy )NIH| Comprehensive proteomic profiling of the ubiquitin pathway in cancer
Dieter A. Wolf; Elizabeth Rico-Bautista;
Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation
The cullin-RING ubiquitin ligase, CRL1(SKP2), directing the degradation of the tumor suppressor p27, is a well validated drug target in a wide variety of human cancers. In this issue of Chemistry & Biology, Wu and colleagues describe first-in-class small molecule inhibitors of CRL1(SKP2)-mediated degradation of p27.
- Sanford Burnham Prebys Medical Discovery Institute United States
Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Biochemistry, Molecular Biology
Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Biochemistry, Molecular Biology
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).20 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 20
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Average
Top 10%
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Cancer Research