Circulating lymphocyte subsets in second- and third-trimester fetuses: Comparison with newborns and adults
Copyright policy )Circulating lymphocyte subsets in second- and third-trimester fetuses: Comparison with newborns and adults
Our objective was to compare the relative sizes of circulating lymphocyte subsets in fetuses, newborns, and adults.Two-color flow cytometric analysis of lymphocyte cell surface markers was performed on blood from 64 fetuses, 22 newborns, and 67 normal adults.All three groups had similar percentages of CD3+ total T cells, CD4+ helper T cells, CD8+ cytotoxic/suppressor T cells, and CD20+ B cells. Compared with adults, fetuses and newborns had markedly reduced percentages of CD57+ natural killer T cells and consistently increased percentages of CD5+CD20+ B cells. Most fetal and cord T and B lymphocytes expressed the activation marker CD38.Similarities and age-dependent differences exist among fetal, newborn, and adult circulating lymphocyte subsets. Lymphocyte marker analysis may prove useful in the detection of fetal infection and other complications of gestation.
- Wayne State University United States
- Wayne State College United States
Adult, B-Lymphocytes, Blood Cells, Pregnancy Trimester, Third, T-Lymphocytes, Infant, Newborn, Gestational Age, Fetal Blood, Lymphocyte Activation, Antigens, Differentiation, Lymphocyte Subsets, Killer Cells, Natural, Pregnancy, Pregnancy Trimester, Second, Humans, Female
Adult, B-Lymphocytes, Blood Cells, Pregnancy Trimester, Third, T-Lymphocytes, Infant, Newborn, Gestational Age, Fetal Blood, Lymphocyte Activation, Antigens, Differentiation, Lymphocyte Subsets, Killer Cells, Natural, Pregnancy, Pregnancy Trimester, Second, Humans, Female
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