Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer’s Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase
Copyright policy )Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer’s Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase
Enzymes of glutamate and GABA metabolism in postmortem cerebellum from patients with Alzheimer's disease (AD) have not been comprehensively studied. The present work reports results of original comparative study on levels of phosphate-activated glutaminase (PAG) and glutamic acid decarboxylase isoenzymes (GAD65/67) in autopsied cerebellum samples from AD patients and matched controls (13 cases in each group) as well as summarizes published evidence for altered levels of PAG and GAD65/67 in AD brain. Altered (decreased) levels of these enzymes and changes in links between amounts of these enzymes and other glutamate-metabolizing enzymes (such as glutamate dehydrogenase and glutamine synthetase-like protein) in AD cerebella suggest significantly impaired glutamate and GABA metabolism in this brain region, which was previously regarded as not substantially involved in AD pathogenesis.
- Russian Academy of Sciences Russian Federation
- Russian Academy
Aged, 80 and over, Glutamate Decarboxylase, Glutamic Acid, Nerve Tissue Proteins, Middle Aged, Glutamate Dehydrogenase, Glutaminase, Alzheimer Disease, Amide Synthases, Cerebellum, Humans, gamma-Aminobutyric Acid, Aged
Aged, 80 and over, Glutamate Decarboxylase, Glutamic Acid, Nerve Tissue Proteins, Middle Aged, Glutamate Dehydrogenase, Glutaminase, Alzheimer Disease, Amide Synthases, Cerebellum, Humans, gamma-Aminobutyric Acid, Aged
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