A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Copyright policy )A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community.
- East Tennessee State University United States
- New York University United States
- National Institutes of Health United States
- Roswell Park Cancer Institute United States
- Howard Hughes Medical Institute United States
Central Nervous System, Homeodomain Proteins, Chromosomes, Artificial, Bacterial, Membrane Glycoproteins, Gene Expression Profiling, Genetic Vectors, Green Fluorescent Proteins, LIM-Homeodomain Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, Mice, Transgenic, Cyclic Nucleotide Phosphodiesterases, Type 1, Axons, Luminescent Proteins, Mice, Cell Movement, Genes, Reporter, Animals, Cell Lineage, Gene Library
Central Nervous System, Homeodomain Proteins, Chromosomes, Artificial, Bacterial, Membrane Glycoproteins, Gene Expression Profiling, Genetic Vectors, Green Fluorescent Proteins, LIM-Homeodomain Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, Mice, Transgenic, Cyclic Nucleotide Phosphodiesterases, Type 1, Axons, Luminescent Proteins, Mice, Cell Movement, Genes, Reporter, Animals, Cell Lineage, Gene Library
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