A role for β-melanocyte-stimulating hormone in human body-weight regulation
Copyright policy )A role for β-melanocyte-stimulating hormone in human body-weight regulation
Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans.
- Leibniz Association Germany
- University of Salford United Kingdom
- University of Duisburg-Essen Germany
- Hannover Medical School Germany
- University of Cincinnati United States
genetics: Homeostasis, Physiology, Molecular Sequence Data, Medizin, Hypothalamus, Mutation, Missense, metabolism: Hypothalamus, beta-MSH, Homeostasis, Humans, genetics: beta-MSH, Amino Acid Sequence, Genetic Testing, Obesity, genetics: Body Weight, Molecular Biology, genetics: Obesity, Base Sequence, Genetic Screening, Body Weight, DNA, Cell Biology, Sequence Analysis, DNA, genetics: Energy Metabolism, Immunohistochemistry, genetics: Mutation, genetics: Mutation, Missense, Missense, Energy Metabolism, Sequence Analysis, Sequence Alignment
genetics: Homeostasis, Physiology, Molecular Sequence Data, Medizin, Hypothalamus, Mutation, Missense, metabolism: Hypothalamus, beta-MSH, Homeostasis, Humans, genetics: beta-MSH, Amino Acid Sequence, Genetic Testing, Obesity, genetics: Body Weight, Molecular Biology, genetics: Obesity, Base Sequence, Genetic Screening, Body Weight, DNA, Cell Biology, Sequence Analysis, DNA, genetics: Energy Metabolism, Immunohistochemistry, genetics: Mutation, genetics: Mutation, Missense, Missense, Energy Metabolism, Sequence Analysis, Sequence Alignment
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