The Piragua Gene Is not Essential for Drosophila Development
Copyright policy )The Piragua Gene Is not Essential for Drosophila Development
Proteins with clusters of C2H2 zinc finger domains (C2H2-proteins) constitute the most abundant class of transcription factors in higher eukaryotes. N-terminal ZAD (zinc finger-associated domain) dimerization domain has been identified in a large group of C2H2-proteins mostly in insects. The piragua gene encodes one of these proteins, Fu2. We have generated CRISPR/Cas9-mediated deletion of the piragua gene that has no phenotype. We have used φC31-mediated attP/attB recombination to generate a transgenic line expressing Fu2 protein fused with HA epitope. This line will be useful for analysis of DNA binding profile and functions of Fu2 protein.
- Russian Academy of Sciences Russian Federation
- Institute of Gene Biology Russian Federation
Animals, Drosophila Proteins, Drosophila, Zinc Fingers, Carrier Proteins, Transcription Factors
Animals, Drosophila Proteins, Drosophila, Zinc Fingers, Carrier Proteins, Transcription Factors
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