Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer
Copyright policy )Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer
Few potential regulatory proteins of vertebrate retinal development have been identified. We describe a 39 kDa murine polypeptide (Chx10) with a homeodomain 82% identical to that of the nematode protein ceh-10. In the developing mouse, the Chx10 transcript is expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup. In the mature retina, the Chx10 protein is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin. Chx10 transcripts are also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord. The data suggest that Chx10 plays critical roles in the formation of the neuroretina and in the development and maintenance of the inner nuclear layer.
- University of Toronto Canada
- Hospital for Sick Children Canada
Homeodomain Proteins, Motor Neurons, Brain Mapping, Base Sequence, Sequence Homology, Amino Acid, Helix-Loop-Helix Motifs, Molecular Sequence Data, Genes, Homeobox, Brain, Gene Expression, Retina, Mice, Genes, Morphogenesis, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Sequence Alignment, In Situ Hybridization
Homeodomain Proteins, Motor Neurons, Brain Mapping, Base Sequence, Sequence Homology, Amino Acid, Helix-Loop-Helix Motifs, Molecular Sequence Data, Genes, Homeobox, Brain, Gene Expression, Retina, Mice, Genes, Morphogenesis, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Sequence Alignment, In Situ Hybridization
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