Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
Copyright policy )Importance of group X–secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A2s (PLA2s), most notably cytosolic PLA2-α. 10 secreted PLA2s (sPLA2s) have also been identified, but their function in eicosanoid generation is poorly understood. We investigated the role of group X sPLA2 (sPLA2-X), the sPLA2 with the highest in vitro cellular phospholipolysis activity, in acute and chronic mouse asthma models in vivo. The lungs of sPLA2-X−/− mice, compared with those of sPLA2-X+/+ littermates, had significant reduction in ovalbumin-induced infiltration by CD4+ and CD8+ T cells and eosinophils, goblet cell metaplasia, smooth muscle cell layer thickening, subepithelial fibrosis, and levels of T helper type 2 cell cytokines and eicosanoids. These data direct attention to sPLA2-X as a novel therapeutic target for asthma.
- Turku University Hospital Finland
- UNIVERSITY OF WASHINGTON
- Washington State University United States
- Howard Hughes Medical Institute United States
- University of Washington United States
Inflammation, Mice, Knockout, Metaplasia, Articles, Allergens, Asthma, Gene Expression Regulation, Enzymologic, Phospholipases A, Disease Models, Animal, Mice, Phospholipases A2, Th2 Cells, Animals, Cytokines, Eicosanoids, Group X Phospholipases A2
Inflammation, Mice, Knockout, Metaplasia, Articles, Allergens, Asthma, Gene Expression Regulation, Enzymologic, Phospholipases A, Disease Models, Animal, Mice, Phospholipases A2, Th2 Cells, Animals, Cytokines, Eicosanoids, Group X Phospholipases A2
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).184 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!