Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform
Copyright policy )Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform
Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor–A (PR-A) and progesterone receptor–B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.
- Baylor College of Medicine United States
Male, Ovulation, Ovariectomy, knockout, Epithelium, Mice, progesterone receptor-A, Mammary Glands, Animal, Animals, Protein Isoforms, Embryo Implantation, Crosses, Genetic, Progesterone, Mice, Knockout, Estradiol, Reproduction, Uterus, Epithelial Cells, progesterone receptor-A ; and progesterone receptor-B ; knockout, Gene Expression Regulation, Female, Receptors, Progesterone, and progesterone receptor-B, Cell Division
Male, Ovulation, Ovariectomy, knockout, Epithelium, Mice, progesterone receptor-A, Mammary Glands, Animal, Animals, Protein Isoforms, Embryo Implantation, Crosses, Genetic, Progesterone, Mice, Knockout, Estradiol, Reproduction, Uterus, Epithelial Cells, progesterone receptor-A ; and progesterone receptor-B ; knockout, Gene Expression Regulation, Female, Receptors, Progesterone, and progesterone receptor-B, Cell Division
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).638 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!